Risk of frailty in older women dependent on multisystem abnormalities
A study published online ahead of press in the Gerontology Society of America's Journal of Gerontology: Medical Sciences reports that the condition of frailty in older adults is associated with a critical mass of abnormal physiological systems, over and above the status of each individual system, and that the relationship is nonlinear. This research is the first evidence that frailty is related to the number of abnormal physiological systems, rather than a specific system abnormality, a chronic disease, or chronological age. It suggests significant alterations in system biology with aging, and underlying frailty. Clinical implications are that prevention and treatment may be more likely to be effective if any given intervention improves multiple systems, not just one.