Ouch! Abrupt opioid withdrawal increases pain sensitivity

Friday, July 10, 2009 - 12:21 in Health & Medicine

(PhysOrg.com) -- The abrupt withdrawal of morphine-like analgesics - opioids - can increase sensitivity to pain. Experiments have now shown that this effect is caused by a memory-like process, the long-term potentiation of synaptic strength in the spinal cord. The study, which was supported by the Austrian Science Fund (FWF), also found ways of avoiding this increase in pain sensitivity. These pioneering results have now been published in the prestigious journal Science.

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