Genetic variant predicts poor response to bypass surgery

A variant of the gene for the inflammatory modulator interleukin (IL)-18 has been found to be associated with a prolonged ICU stay after cardiopulmonary bypass (CPB) surgery. Research published in BioMed Central's open access journal Critical Care links the TT genotype of the IL-18 9545 T/G polymorphism with a larger pro-inflammatory response.

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