DNA research taking guesswork out of finding the 'therapeutic window'

It's only spit, but what's inside your saliva may help solve a dosing dilemma facing doctors and patients. By using DNA to customize prescriptions, researchers at Temple University's School of Pharmacy are working to prevent adverse drug reactions before you even take the first dose. Each year, adverse drug reactions kill or injure more than 770,000 people in this country, according to the U.S. Department of Health & Human Services. At the top of the list of problem drugs is Warfarin, (Coumadin(R)), the most widely prescribed anticoagulant. That is why Evgeny Krynetskiy, Ph.D., associate professor and director of the Jayne Haines Center for Pharmacogenomics and Drug Safety, has focused his research efforts on that drug.

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