The neuropeptide Y system is linked to a more severe form of alcohol dependence

Tuesday, September 23, 2008 - 15:42 in Psychology & Sociology

Previous animal research showed an association between the neuropeptide Y (NPY) pathway and its three receptor genes and response to alcohol and cocaine. A new study has examined the relationship of the human NPY system with alcohol dependence (AD), with and without withdrawal symptoms, and cocaine dependence. Two receptor genes in particular, NPY2R and NPY5R, were found to be associated with a more severe subtype of AD - characterized by withdrawal symptoms or coexisting alcohol and cocaine dependence - and cocaine dependence.

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