Mammalian Aging Process Linked to Overactive Cellular Pathway
Wednesday, December 22, 2010 - 14:00
in Health & Medicine
Whitehead Institute researchers have linked hyperactivity in the mechanistic target of rapamycin complex 1 (mTORC1) cellular pathway to reduced ketone production in the liver, which is a well-defined physiological trait of aging in mice. As animals age, their ability to produce ketones in response to fasting declines.