How infection can lead to cancer
One of the biggest risk factors for liver, colon or stomach cancer is chronic inflammation of those organs, often caused by viral or bacterial infections. A new study from MIT offers the most comprehensive look yet at how such infections provoke tissues into becoming cancerous.The study, which is appearing in the online edition of Proceedings of the National Academy of Sciences the week of June 11, tracked a variety of genetic and chemical changes in the livers and colons of mice infected with Helicobacter hepaticus, a bacterium similar to Helicobacter pylori, which causes stomach ulcers and cancer in humans. The findings could help researchers develop ways to predict the health consequences of chronic inflammation, and design drugs to halt such inflammation. “If you understand the mechanism, then you can design interventions,” says Peter Dedon, an MIT professor of biological engineering. “For example, what if we develop ways to block or...