Moving past trial and error
Richard Braatz Photo: Dominick Reuter Trial-and-error experimentation underlies many biomedical innovations. This classic method — define a problem, test a proposed solution, learn from failure and try again — is the main route by which scientists discover new biomaterials and drugs today. This approach is also used to design ways of manufacturing these new materials, but the process is immensely time-consuming, producing a successful therapeutic product and its manufacturing process only after years of experiments, at considerable expense. Richard Braatz, the Edwin R. Gilliland Professor of Chemical Engineering at MIT, applies mathematics to streamline the development of pharmaceuticals. Trained as an applied mathematician, Braatz is developing mathematical models to help scientists quickly and accurately design processes for manufacturing drug compounds with desired characteristics. Through mathematical simulations, Braatz has designed a system that significantly speeds the design of drug-manufacturing processes; he is now looking to apply the same mathematical approach to...