Structural study backs new model for the nuclear pore complex

Monday, December 29, 2008 - 12:40 in Physics & Chemistry

Inside the cell nucleus, DNA is transcribed into RNA that then leaves the nucleus and binds to the cell’s ribosomes, where it is translated into proteins. But in order to get to the ribosome, the RNA must pass through a relatively large, complicated and little-understood structure called the nuclear pore complex. Researchers at The Rockefeller University have a new model for the gatekeeper to the nucleus and have discovered the crystal structure of a protein pair that backs it up.

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