An enzyme that mutates antibodies also targets a cancer-causing oncogene

The human immune system runs a risky business. It mutates its own DNA to diversify defenses against foreign invaders it has never before encountered. Unfortunately, these mutations sometimes miss the mark, and the result can be lethal cancer. Now Rockefeller University scientists have found that the same enzyme that enables an effective immune response is also responsible for the DNA breaks that cause lymphomas.

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