Evading MicroRNA Control By Differential Poly-Adenylation Patterns-

Thursday, June 7, 2012 - 12:01 in Biology & Nature

Refer to: Boutet et al. Cell Stem Cell 10, 327–336, March 2, 2012A major function of microRNAs is to inhibit messenger RNA (mRNA) translation by binding to a specific 3’ untranslated region (UTR) through sequence complementation. In this study, Boutet et al. discovered that Pax3 transcripts in muscle stem cells in vivo can have both long and short 3’UTRs, an effect controlled by differential poly-adenylation patterns during the course of development. While Pax3 transcripts with long 3’UTRs are susceptible to translational inhibition by miR-206, transcripts with short 3’UTR are profoundly resistant to miR-206.  read more

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