Mice Cheer Up After Knockout
Friday, November 13, 2009 - 11:07
in Biology & Nature
Mice who had the PKCI/HINT1 gene removed had an anti-depressant-like and anxiolytic-like effect, say esearchers writing in BMC Neuroscience who applied a battery of behavioral tests to the PKCI/HINT1 knockout animals, concluding that the deleted gene may have an important role in mood regulation. Elisabeth Barbier and Jia Bei Wang, from the School of Pharmacy at the University of Maryland, USA, carried out the experiments to investigate the role of the gene in regulating mood function. Wang, the corresponding author of the paper, said, "The knockout mice displayed behaviors indicative of changes in mood function, such as increased perseverance and reduced anxiety in open spaces". read more