High-fidelity CRISPR-Cas9 nucleases have no detectable off-target mutations
Wednesday, January 6, 2016 - 15:08
in Physics & Chemistry
A new engineered version of the gene-editing CRISPR-Cas9 nuclease appears to robustly abolish the unwanted, off-target DNA breaks that are a significant current limitation of the technology, reducing them to undetectable levels.