DNA origami puts a smart lid on solid-state nanopore sensors

The latest advance in solid-state nanopore sensors -- devices that are made with standard tools of the semiconductor industry yet can offer single-molecule sensitivity for label-free protein screening -- expands their bag of tricks through bionanotechnology. Researchers have enhanced the capabilities of solid-state nanopores by fitting them with cover plates made of DNA. These nanoscale cover plates, with central apertures tailored to various "gatekeeper" functions, are formed by so-called DNA origami techniques.

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