Sensing self and non-self: New research into immune tolerance
Monday, February 13, 2012 - 20:30
in Health & Medicine
Cancer cells can undergo unchecked proliferation, producing self-antigens that are tolerated by the immune system, rather than being targeted for destruction. At the opposite extreme, autoimmune disorders can result when healthy cells in the body are misidentified as hazards. Researchers now examine how CD8 T cells -- critical weapons in the body's defensive arsenal -- are regulated when they transition from this tolerant state to an activated state and back.