A new target to inhibit malaria and toxoplasmosis infection
Monday, July 25, 2011 - 11:31
in Biology & Nature
Scientists have characterized a protein complex that allows the agents that cause malaria and toxoplasmosis to infect host cells. This is a highly original mechanism, since the parasite supplies both the receptor which it inserts into the host cell membrane and the ligand it exposes at its surface. The researchers have now shown the three-dimensional structure of this complex. The new data paves the way for new drugs designed to inhibit the formation of the protein complex in question and block invasion by Plasmodium falciparum in red blood cells.