Blood-brain barrier damaged by Sanfilippo syndrome type B disease, mouse study suggests

When modeled in mice, Sanfilippo syndrome type B (MS III B), has been found to damage the blood-brain barrier, the structure responsible for protecting the brain from the entry of harmful blood-borne substances. Before this study, little was known about the integrity of the blood-brain barrier in this disease. The discovery of blood-brain barrier structural and functional impairment in MPS III B mice may have implications for disease pathogenesis and treatment.

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