Parkinson's disease may be caused by microtubule, rather than mitochondrial complex I, dysfunction

Monday, March 7, 2011 - 15:30 in Health & Medicine

Patients with Parkinson's disease suffer a specific loss of dopaminergic neurons from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is unclear, though many lines of evidence point to dysfunctional mitochondrial complex I as one root cause of the disease. Yet new research now suggests that defective regulation of microtubules may be responsible for at least some cases of PD.

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