Strategy For Mismatched Stem Cell Transplants Triggers Protection Against Graft-vs.-host Disease

A technique being tested in stem cell transplants from imperfectly matched donors has revealed an unforeseen response that can suppress graft-versus-host disease. The previously unrecognized specificity of regulatory T cells helps explain why the patients treated with the new strategy -- known as "co-stimulatory blockade" -- have shown a low level of GVHD. The findings suggest that the technique might prove valuable in solid organ transplants, as well as in treating autoimmune disease.

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