Key Event In Prostate Cancer Progression Discovered
Monday, July 27, 2009 - 16:21
in Health & Medicine
Researchers have discovered how hormone-dependent prostate cancer advances to the incurable hormone-independent disease state. The study shows that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate genes involved in a later phase of cell division. A small epigenetic change in a gene called UBE2C is responsible for this reprogramming. Increased expression of that gene correlated with progression to the hormone-independent phase.