In Rare Disease, A Familiar Protein Disrupts Gene Function
Thursday, May 28, 2009 - 20:28
in Biology & Nature
Scientists studying a rare genetic disease discovered that a bundle of proteins with the long-established function of keeping chromosomes together also plays an important role in regulating genes in humans. When cohesin, a protein complex, doesn't work properly, genes are dysregulated in the multisystem developmental disease Cornelia de Lange syndrome.