Metastasis-promoting Protein In Urine Identified; Could Provide A Prognostic Test Or Target For Breast Cancer
Tuesday, February 24, 2009 - 23:28
in Health & Medicine
A small protein detectable in urine can predict a breast cancer's aggressiveness, and possibly provide a new avenue for treating the disease. When its production is shut down, cell migration -- a key step in progression and metastasis -- is inhibited. The protein, which has been licensed for clinical development, also plays a key biological role in advancing cancer, triggering the epithelial-to-mesenchymal transition and reducing cells' response to the hormone estrogen.