Misreading Of Damaged DNA May Spur Tumor Formation

Cells can turn on tumor-promoting growth circuits by falsely reporting critical genetic information during the process of transcription: making RNA from DNA. Damage to the DNA making up a gene can lead to a misreading of the gene as it is made into RNA, a process called transcriptional mutagenesis. Transcriptional mutagenesis could represent an additional way DNA damage contributes to tumor formation.

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