Lou Gehrig's Protein Found Throughout Brain, Suggesting Effects Beyond Motor Neurons

Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with Lou Gehrig's disease. Now, the same group has shown that TDP-43 accumulates throughout the brain, suggesting the disease has broader neurological effects than previously appreciated and treatments need to take into account more than motor neuron areas.

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