New Cancer Stem Cell Driving Metastatic Tumors Identified

The molecular profile of cancer stem cells that initiate metastatic colon tumors is significantly different from those responsible for primary tumors, according to new research. New data, generated by analysis of human colon cancer cells and mice, have shed doubt on the recently proposed designation of the protein CD133 as a marker of colon cancer stem cells -- a term given to the small number of cells within a colon cancer that are thought to be able to give rise to a new tumor and that therefore are responsible for tumor recurrence and metastasis.

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