Exhaustion Of HIV-specific T Cells May Be Caused By Chronic Exposure To Virus

Tuesday, May 6, 2008 - 12:14 in Health & Medicine

The "exhaustion" of immune cells that target HIV appears to result from chronic exposure to the virus, specifically exposure to the protein segments targeted by the pathogen-killing HIV-specific CD8 T cells. A study from researchers at the Partners AIDS Research Center at Massachusetts General Hospital may have answered a key question: whether the functional impairment of these T cells is the cause or the result of unchecked viral replication in chronic progressive HIV-1 infection?

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