Arterial infusion using gabexate mesilate: Is it effective therapy for severe acute pancreatitis?

Severe acute pancreatitis (SAP) remains a lethal disease. It is defined as an inflammatory process of the pancreas with possible peripancreatic tissue and multi-organ involvement inducing multi-organ dysfunction syndrome (MODS) with an increased mortality rate. Protease inhibitors are widely applied to treat acute pancreatitis in Japan, but the protease inhibitors used to treat acute necrotising pancreatitis cannot easily reach the pancreas when administered intravenously, and, because of ischaemia or impaired microcirculation, they hardly penetrate into pancreatic tissue...

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