Pitt scientists find intrinsic changes in protein shape influence drug binding
Wednesday, August 19, 2009 - 12:15
in Biology & Nature
PITTSBURGH, Aug. 19 -- Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also allows the small molecules that are attracted to a given protein to select the structure that permits the best binding.