A Dose of Embryonic Cells Could Induce Infant-Like 'Plasticity' in Brain, Allowing it to Rewire Itself Like New

Monday, March 29, 2010 - 10:49 in Biology & Nature

The brain is the body's most complicated biological machine, and as such it can be very difficult to service when something goes wrong; after our neural wiring is put in place, at a very young age, altering or rebuilding it becomes extremely challenging. But researchers at UC San Francisco have figured out a way to induce a new period of "plasticity" -- a state in which neural circuitry is receptive to change -- in the visual cortices of mice, a breakthrough that could lead to treatments for brain circuits damaged by developmental problems or traumas. All regions of the brain go through periods of high plasticity at various times in the development process during early life. During this time, neurons are highly responsive to signals -- in the case of the visual cortex, visual signals -- that shape the way they will function going forward. Through a process known as synaptic...

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