How a protein stops cells from attacking their own DNA
Thursday, August 13, 2020 - 15:30
in Biology & Nature
Viruses multiply by injecting their DNA into a host cell. Once it enters the intracellular fluid, this foreign material triggers a defense mechanism known as the cGAS-STING pathway. The protein cyclic GMP-AMP Synthase (cGAS), which is also found inside the fluid, binds to the invading DNA to create a new molecule. This, in turn, binds to another protein called Stimulator of Interferon Genes (STING), which induces an inflammatory immune response.