Transcription factor regulates protein that dampens immune responses
Friday, June 17, 2011 - 12:31
in Health & Medicine
Interleukin-10 (IL-10) is an anti-inflammatory cytokine protein that reduces immune responses and staves off autoimmune disease. Now, a research team led by Masato Kubo at the RIKEN Research Center for Allergy and Immunology, Yokohama, has identified a transcription factor called E4 promoter-binding protein (E4BP4) that is responsible for driving the expression of IL-10 in multiple types of immune cells.