Research highlights immune molecule’s complex role in Huntington’s disease
More than a decade before people with Huntington’s disease (HD) show symptoms, they can exhibit abnormally high levels of an immune-system molecule called interleukin-6 (IL-6), which has led many researchers to suspect IL-6 of promoting the eventual neurological devastation associated with the genetic condition. A new investigation by MIT neuroscientists shows that the story likely isn’t so simple. In a recent study they found that Huntington’s model mice bred to lack IL-6 showed exacerbated symptoms compared to HD mice that still had it. “If one looks back in the literature of the Huntington’s disease field, many people have postulated that reductions to IL-6 would be therapeutic in HD,” says Myriam Heiman, associate professor in MIT’s Department of Brain and Cognitive Sciences and a member of The Picower Institute for Learning and Memory and the Broad Institute of MIT and Harvard. She is senior author of the paper in Molecular Neurodegeneration. Former...