Human cells have a finite lifespan: They can only divide a certain number of times before they die. However, that lifespan is reset when reproductive cells are formed, which is why the children of a 20-year-old man have the same life expectancy as those of an 80-year-old man.How that resetting occurs in human cells is not known, but MIT biologists have now found a gene that appears to control this process in yeast. Furthermore, by turning on that gene in aged yeast cells, they were able to double their usual lifespan.If the human cell lifespan is controlled in a similar way, it could offer a new approach to rejuvenating human cells or creating pluripotent stem cells, says Angelika Amon, professor of biology and senior author of a paper describing the work in the June 24 issue of the journal Science.“If we can identify which genes reverse aging, we can start...
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