2 signals -- from within and out of cell -- specify motor neuron differentiation
Wednesday, June 10, 2009 - 17:14
in Biology & Nature
Two signals – an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 – cooperate to activate chromatin (the basic material of chromosomes) and help determine that certain nerve progenitor cells become motor neurons, said researchers from Baylor College of Medicine (www.bcm.edu) in a report in the current issue of the journal Neuron.