Probiotic bacteria can induce monocyte-derived dendritic cells maturation?
Probiotic bacteria are widely used to relieve the symptoms of many disorders such as inflammatory bowel syndrome, diarrhea, and allergies. Probiotic mixtures have also been found to reduce the symptoms of diarrhea. In children a probiotic bacterium L. rhamnosus GG has been shown to prevent the onset of atopy and allergies. However, the mechanisms that cause these beneficial actions are yet to be characterized. One of the factors contributing to the health promoting effects of probiotic bacteria could be their capacity to induce cytokine production that further regulates the development of innate and adaptive immune responses. Cytokines are small signaling molecules secreted by immune cells that direct the activation of innate and adaptive immune responses during microbial infections. Cytokines activate and recruit immune cells to the site of infection and increase host responses to pathogens. Many clinical trials have proven probiotic bacteria to be effective in preventing certain diseases or relieving their symptoms. However, there is a need for novel probiotic bacteria for clinical use.