Study sheds new light on river blindness parasite
The team found that a bacterium inside the worm acts as a 'disguise' for the parasite, resulting in the immune system reacting to it in an ineffective way. The bacteria protect the worm from the body's natural defences, but once the bacteria are removed with antibiotics, the immune system responds appropriately, releasing cells, called eosinophils, that kill the worm. Antibiotics are successful against the parasite, but the long treatment regime means that it has limited use across whole communities. These new findings suggest that if medics could prime the immune system to recognise the worm, a shorter duration of antibiotic treatment may be sufficient to overcome its bacterial defences.
River Blindness is caused by black flies that breed in rivers and deposit the larvae of a worm into the person they bite. The infection leads to severe itching of the skin and lesions of the eye which can result in blindness. It affects millions of people in developing countries, particularly in West and Central Africa. A closely related parasite also infects cattle, which causes lumps to appear on the animal's skin but does not cause blindness or other illness.
Dr Ben Makepeace, from the University's Institute of Infection and Global Health, explains: "Our team has already shown that removing the bacteria with antibiotics results in the death of the worm, but until now we were unaware of how the bacteria protected the parasite in the first instance. Antibiotics can rid the parasite of the bacteria, allowing the immune system to respond properly, but it is a long treatment process, lasting up to six weeks.
"Now we can begin to look for a way to 'prime' the body into reacting to the parasite more efficiently. Currently there is no vaccine for River Blindness, but if a candidate could be identified this may help boost the immune system ahead of antibiotic treatment and reduce the length of time patients have to take the drug. It is essential that whole communities are cured of the infection and the more we know about the mechanisms the parasite uses to survive in the body, the further we can progress with finding a practical treatment that kills adults worms and not just the larval stages"
Source: University of Liverpool
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Vampire squid discovery shows how little we know of the deep sea
- Pulsing light may indicate supermassive black hole merger
- Technology can transfer human emotions to your palm through air, say scientists
- Throwing light on how to conduct a personalized pancreas cancer clinical trial
- Big butts aren't everything to male baboons
- 'Pull my finger!' say scientists who solve knuckle-cracking riddle
- Study links brain anatomy, academic achievement, and family income
- Professional golfers live a lonely life in the midst of rivalries on a meager income
- A call to US educators: Learn from Canada
- For men, online generosity is a competition