Protein injection shows promise in lowering elevated triglycerides
Injecting a protein that helps break down triglycerides may someday help treat an inherited form of high triglycerides, according to a new study in Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal. Triglyceride is a type of fat in the blood. Elevated levels in the blood — hypertriglyceridemia — have been linked to coronary artery disease.
In the study, researchers tested a new compound in mice genetically altered to be deficient in a protein called apolipoprotein (apo)A-V, which causes them to have high blood levels of triglycerides. ApoA-V boosts the efficiency of lipoprotein lipase, an enzyme needed to break down triglycerides. The active compound consists of apoA-V complexed with phospholipid to form a reconstituted high density lipoprotein (HDL). The researchers administered the compound in the mice intravenously.
"We asked a simple question: If you just inject apoA-V into these mice that are lacking apoA-V and have very high levels of triglyceride, will it go down?" said Trudy Forte, Ph.D., study senior author and a scientist at Children's Hospital Oakland Research Institute in California. "We were very gratified to see that it went down, and it continued to do so over an eight-hour period."
By the end of the treatment, triglycerides had dropped about 87 percent.
However, in engineered mice lacking a protein called GPIHBP1, which also leads to very high triglycerides, the apoA-V injection didn't lower levels.
Intravenous apA-V may have a therapeutic benefit in humans with severely elevated triglycerides due to genetic changes that affect their levels of apoA-V, the researchers said.
Source: American Heart Association
- Study sheds light on triglyceride metabolismWed, 7 Jul 2010, 11:31:24 EDT
- Rare and common genetic variations responsible for high triglyceride levels in bloodSun, 25 Jul 2010, 13:29:14 EDT
- Disrupted circadian rhythm may cause triglycerides to riseTue, 3 Aug 2010, 12:37:40 EDT
- Genetic variant increases triglyceride levels in Asian-AmericansThu, 17 Jul 2008, 11:23:27 EDT
- Dietary, lifestyle changes can significantly reduce triglycerides Mon, 18 Apr 2011, 17:03:17 EDT
- Protein injection shows promise in lowering elevated triglyceridesfrom Science CentricSat, 23 Oct 2010, 12:10:19 EDT
- Protein injection shows promise in lowering elevated triglyceridesfrom Science DailyFri, 22 Oct 2010, 14:30:19 EDT
- Protein injection shows promise in lowering elevated triglyceridesfrom PhysorgThu, 21 Oct 2010, 17:20:16 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Researchers reveal model of Sun's magnetic field
- 2 miniature spider species discovered in Giant Panda Sanctuaries of China
- The Norway spruce genome sequenced
- UCLA life scientists present new insights on climate change and species interactions
- Baby's life saved with groundbreaking 3-D printed device that restored his breathing
- Allosaurus fed more like a falcon than a crocodile, new study finds
- Invasive crazy ants are displacing fire ants in areas throughout southeastern US
- Beautiful 'flowers' self-assemble in a beaker
- Scientific insurgents say 'Journal Impact Factors' distort science
- GPS solution provides 3-minute tsunami alerts