Early menopause can result in earlier onset dementia
Women experiencing an early onset of menopause could develop dementia at a younger age. Research by Tonnie Coppus of Erasmus MC has indicated this. She studied women with Down Syndrome, who are known to have an early onset of menopause. The results of her research can be translated to apply to the general population. Her results will be published in the Journal of Alzheimer Disease today. Women with Down Syndrome have an earlier onset of menopause compared to women in the general population, 44 years of age and 52 years of age, respectively. Coppus' findings show a strong relationship between the age of menopause onset and the age at which dementia is diagnosed. Coppus: "Women with Down Syndrome with an early onset of menopause also appear to suffer from dementia at an early age. In addition, my study shows that these women also die younger."
Alzheimer's disease is the major cause of illness and death among people with Down Syndrome. The Epidemiology department of Erasmus MC has been studying more than 500 people with Down Syndrome, above the age of 45, since 2000. In particular, the factors affecting the onset of dementia and death are studied. The health development found within this group is in fact an accelerated version of the developments found in the general population. The research results can therefore be translated to similar results for the general population.
A first step in the development of Alzheimer is the build up of so-called amyloid in the brain. The deposition of this amyloid occurs under influence of a certain gene, higher levels of which are found in people with Down Syndrome. Down Syndrome is a chromosomal disorder in which there are three copies of chromosome 21. This chromosome has various genes that play a role in neurological diseases. The most important of these is the gene that is responsible for the production of the protein amyloid. Coppus: "Studying the various factors that influence the development of Alzheimer's disease among people with Down Syndrome also improves our understanding of the role of amyloid in the development of Alzheimer's disease within the general population."
As it appears, not only can a relationship with the age of onset of dementia be determined but also a relationship between early onset of menopause and dying young. Coppus: "As dementia itself also leads to a reduced life expectancy, I made calculations in which I corrected the results of the effect of dementia on death. Despite this, the relationship between early menopause onset and dying young remains. The research results provide substantial information on the relationship between menopause and dementia and the relationship between menopause and death."
Source: IOS Press
- Exposure to chemicals in environment associated with onset of early menopauseWed, 23 Mar 2011, 8:34:08 EDT
- Early menopause linked to higher risk of future cardiovascular diseaseMon, 21 Jun 2010, 13:37:26 EDT
- Hysterectomy increases risk for earlier menopause among younger womenMon, 14 Nov 2011, 14:34:53 EST
- Global menopause summit concludes HRT is safe for healthy women entering menopauseTue, 20 May 2008, 17:56:39 EDT
- Is rapid transition through menopause linked to earlier onset of heart disease?Tue, 27 Jan 2009, 16:15:06 EST
- Early menopause can result in earlier onset dementiafrom PhysorgWed, 27 Jan 2010, 14:28:30 EST
- Early menopause can result in earlier onset dementiafrom Science DailyWed, 27 Jan 2010, 13:29:15 EST
- Early menopause can result in earlier onset dementiafrom Science BlogWed, 27 Jan 2010, 13:07:30 EST
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Allosaurus fed more like a falcon than a crocodile, new study finds
- Invasive crazy ants are displacing fire ants in areas throughout southeastern US
- Beautiful 'flowers' self-assemble in a beaker
- Scientific insurgents say 'Journal Impact Factors' distort science
- GPS solution provides 3-minute tsunami alerts