Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions. The study, which appears on-line in Obesity, also found that measuring a person's body mass index (BMI) does not reliably predict the amount of undesired fat in and around these vital organs. The prevalence of obesity is rising rapidly in the United States. Recent estimates suggest that approximately 30 percent of the adult population meets this criterion. Past studies have shown that fat accumulation in the liver and around the heart are linked to cardiovascular disease and type 2 diabetes.
BUSM researchers compared fat volumes in obese persons (BMI over 30), all of whom had high blood pressure and/or diabetes, and lean healthy persons (average BMI of 22). All subjects underwent magnetic resonance imaging (MRI) and proton MR spectroscopy to quantify pericardial and peri-aortic lipid volumes, cardiac function, aortic compliance and intra-hepatic lipid content. Fasting plasma lipoproteins, glucose, insulin, and free fatty acids were also measured among the subjects.
The researchers found fat collections in anatomically separate locations, such as within the liver and around the heart, to be associated to cardiovascular function – including a decrease in cardiac pumping function – as fat around the heart increased. However, they also found that the amount of fat around the heart and aorta was not predicted by the BMI of the individual in this population.
"Our study found that fat collection around the heart, the aorta and within the liver is clearly associated with decreased heart functions and that an MRI can quickly and noninvasively measure fat volume in these areas. Our study also found that looking at BMI of the individual does not reliably predict the amount of undesired fat in and around organs," said James
Hamilton, PhD, senior author and project leader, and a professor of biophysics, physiology and biomedical engineering at BUSM.
According to the researchers, this method of measuring cardiac function and fat depots can be done in less than one hour, and may provide a basis for future individualized treatment.
Source: Boston University Medical Center
- Fat collections linked to decreased heart functionfrom Science CentricSun, 15 Nov 2009, 10:56:13 EST
- Fat Collections Linked To Decreased Heart Functionfrom Science DailyFri, 13 Nov 2009, 11:35:19 EST
- Fat collections linked to decreased heart functionfrom Science BlogFri, 13 Nov 2009, 10:49:18 EST
- Fat collections linked to decreased heart functionfrom PhysorgFri, 13 Nov 2009, 10:28:09 EST
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Berkeley Lab study reveals molecular structure of water at gold electrodes
- Genomic data support early contact between Easter Island and Americas
- Paper-based synthetic gene networks could enable rapid detection of ebola and other viruses
- Helping sweet cherries survive the long haul
- No-till agriculture may not bring hoped-for boost in global crop yields, study finds
- POLARBEAR seeks cosmic answers in microwave polarization
- Thermal paper cash register receipts account for high bisphenol A (BPA) levels in humans
- Exploring X-Ray phase tomography with synchrotron radiation
- UNH scientist: Cosmic rays threaten future deep-space astronaut missions
- Secrets of dinosaur ecology found in fragile amber
- Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents
- Earth's water is older than the sun
- Preference for built-up habitats could explain rapid spread of the tree bumblebee in UK
- Tooth buried in bone shows prehistoric predators tangled across land, sea
- Simulations reveal an unusual death for ancient stars