New technology discovery at Mount Sinai Hospital holds promise for improved breast cancer treatment
In a study published by Nature Biotechnology online on February 1, 2009, Mount Sinai Hospital researchers have unveiled a new technology tool that analyzes breast cancer tumours to determine a patient's best treatment options. The tool can predict with more than 80 per cent accuracy a patient's chance of recovering from breast cancer. "Breast cancer is the most common cancer in Canadian women," said Dr. Jeff Wrana, Senior Investigator and the Mary Janigan Research Chair in Molecular Cancer Therapeutics at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, and an International Scholar of the Howard Hughes Medical Institute. "Our hope with this technology is to eventually provide individualized analysis to breast cancer patients and their oncologists so that they are better informed and empowered to select a treatment best suited to them."
The technology, called 'DyNeMo' analyzes networks of proteins in cancer cells. Analysis of more than 350 patients found that those who survive breast cancer have a different organization of the network of proteins within the tumour cells, compared with patients who succumbed to the illness. DyNeMo can be used to predict the outcome in a newly diagnosed breast cancer patient and then assist clinicians and patients in making informed decisions on treatment. The study was led by the Mount Sinai Hospital team and co-authored by researchers at the University of Toronto and London, England's The Institute for Cancer Research.
In the future, this tool may be used to analyze other types of cancer and could be used to predict an individual's response to particular drugs.
"This research brings us one step closer to delivering individualized medicine in which healthcare professionals will be able to provide more accurate and personalized diagnoses and treatments," said Dr. Jim Woodgett, Director of Research for the Samuel Lunenfeld Research Institute of Mount Sinai Hospital.
The research was funded by Genome Canada with funds from Ontario Genomics Institute, and the Canadian Breast Cancer Foundation (CBCF) – Ontario Region. The CBCF's Interim CEO Beth Easton said the Foundation, "is pleased to play a role, along with others, in supporting the basic science behind this exciting development for breast cancer patients."
To bring this technology to patients, Mount Sinai Hospital is working to partner with the biotechnology industry, and estimates that the tool will be available to healthcare providers within the next five years.
Articles on the same topic
- PET/CT may improve prognosis for patients with inflammatory breast cancerMon, 2 Feb 2009, 10:35:56 EST
- Automated screening process may eventually reduce additional breast cancer surgeriesFri, 30 Jan 2009, 12:43:22 EST
- Breast cancer drug shows promise for treating, preventing progestin-dependent tumorsWed, 28 Jan 2009, 14:37:05 EST
- Many women who survived childhood cancer do not undergo recommended breast cancer screeningTue, 27 Jan 2009, 16:22:22 EST
- Study examines risk factors for cancer in unaffected breast of breast cancer patientsMon, 26 Jan 2009, 0:22:25 EST
- Researchers identify risk factors for contralateral breast cancerMon, 26 Jan 2009, 0:22:17 EST
- New technology holds promise for predicting breast cancer recoveryfrom CBC: Technology & ScienceMon, 2 Feb 2009, 12:58:00 EST
- New technology holds promise for predicting breast cancer recoveryfrom CBC: HealthMon, 2 Feb 2009, 12:56:09 EST
- New tool predicts women's outcome in breast cancerfrom Reuters:ScienceMon, 2 Feb 2009, 10:56:09 EST
- New tool predicts women's outcome in breast cancerfrom Reuters:ScienceSun, 1 Feb 2009, 18:14:06 EST
- New Promise For Improved Breast Cancer Treatmentfrom Science DailySun, 1 Feb 2009, 15:29:01 EST
- New technology discovery holds promise for improved breast cancer treatmentfrom PhysorgSun, 1 Feb 2009, 15:08:01 EST
- Automated screening process may eventually reduce additional breast cancer surgeriesfrom Science CentricSun, 1 Feb 2009, 13:49:15 EST
- Automated screening process may eventually reduce additional breast cancer surgeriesfrom PhysorgFri, 30 Jan 2009, 12:56:21 EST
- Breast cancer drug shows promise for treating, preventing progestin-dependent tumorsfrom PhysorgWed, 28 Jan 2009, 14:56:12 EST
- Many women who survived childhood cancer do not undergo recommended breast cancer screeningfrom Science CentricWed, 28 Jan 2009, 14:07:53 EST
- Childhood cancer survivors lag in mammogram screenings: studyfrom CBC: HealthTue, 27 Jan 2009, 18:07:31 EST
- Guiding preventive mastectomy decisions aim of researchersfrom CBC: HealthTue, 27 Jan 2009, 12:49:10 EST
- An individualized approach to breast cancer treatmentfrom PhysorgMon, 26 Jan 2009, 16:14:09 EST
- Risk Factors For Contralateral Breast Cancer Identifiedfrom Science DailyMon, 26 Jan 2009, 9:56:14 EST
- Researchers identify risk factors for contralateral breast cancerfrom Science CentricMon, 26 Jan 2009, 9:52:21 EST
- Study examines risk factors for cancer in unaffected breast of breast cancer patientsfrom Science CentricMon, 26 Jan 2009, 9:50:56 EST
- Researchers identify risk factors for contralateral breast cancerfrom PhysorgMon, 26 Jan 2009, 3:42:08 EST
- Reduced breast cancer risk: Physical activity after menopause pays offfrom Science CentricSat, 24 Jan 2009, 11:56:31 EST
- Breastfeeding May Prevent Breast Cancerfrom Science DailyThu, 22 Jan 2009, 9:15:37 EST
- Reduced Breast Cancer Risk: Physical Activity After Menopause Pays Offfrom Science DailyTue, 20 Jan 2009, 10:14:55 EST
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Long-necked 'dragon' discovered in China
- Erratic as normal: Arctic sea ice loss expected to be bumpy in the short term
- To reassure electric car buyers, combine battery leasing with better charging: INFORMS study
- Quantum computer as detector shows space is not squeezed
- CAT scan of nearby supernova remnant reveals frothy interior
- Climate affects the development of human speech
- Why all-nighters don't work: How sleep and memory go hand-in-hand
- H.E.S.S. finds three extremely luminous gamma-ray sources
- Clemson researcher explores how the universe creates reason, morality
- Study shows Brazil's Soy Moratorium still needed to preserve Amazon