Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumour suppressor genes, p16 and p19, in the ageing process. Scientists knew that both these genes ...
Researchers at the University of Southern California (USC) have identified a specific tumour suppressor that manages membrane traffic routes for cellular cleaning and recycling...
... 8 July issue of the journal Cancer Cell, advances the understanding of one of the most frequently disrupted tumour suppressor proteins in human cancer and provides new insight into the regulation of ...
Genes that inhibit the spontaneous development of cancer are called tumour suppressor genes. One of the major tumour suppressors is p53, a protein that acts in the cell nucleus to control the ...
Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumour suppressor that may help scientists develop more targeted drug therapies to combat lung cancer...
... have found that the experimental drug they are testing to treat a deadly form of thyroid cancer turns on a powerful tumour suppressor capable of halting cell growth. Few other cancer ...
... study, published by Cell Press in the February issue of the journal Developmental Cell, also reveals an intriguing but unexpected regulatory role for a tumour suppressor gene in fibrotic disease...
... University of Texas M. D. Anderson Cancer Centre have discovered a gene that protects PTEN, a major tumour-suppressor that is reduced but rarely mutated in about half of all breast ...
Researchers have identified a new candidate tumour suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online 17 ...
... The University of Texas M. D. Anderson Cancer Centre have identified a protein that marks the tumour suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells ...
A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumour suppressor p53, which made its name as 'guardian of the genome,' not only stops cells that ...
The PTEN tumour suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration ...
... of Sciences (PNAS) in an advanced edition.
Protein p53 is considered the most important tumour suppressor and it is at the centre of the machinery that regulates cell cycle arrest and the death of ...
A small piece of RNA, or microRNA (miRNA), ratchets down the activity of the tumour-suppressor gene p53, according to a study by Whitehead Institute and National University of Singapore researchers... ...
... and apoptosis is inhibited. Thereby the gene plays a decisive role in the development of many tumours. The problem is that pharmacological substances do not target Myc as it does not have enzymatic ...
