... . "The Australians have worked out how viruses identify our nuclear ZIP-code, and have delivered therapeutic genes to the same address. This work opens up a new era of pharmaceutical development."
... therapy trials are expensive because scientists must administer so much of the vector containing the therapeutic gene to see results. Using the new vector, scientists could potentially scale back to ...
... question in a first-ever clinical trial of gene therapy to treat severe heart failure. ... molecule called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, ...
... states "these results set the stage for our future use of this technology to deliver therapeutic genes to lessen the severity of restenosis which is the most common issue following angioplasty and ...
... for pain, and the first study to test a nonreplicating HSV-based vector to deliver a therapeutic gene to humans. Fink says the technique may hold promise for treating other types of chronic pain, ...
... MGH team examined whether expression of a therapeutic gene in normal brain cells could form ... originate also produced similar results. While other gene therapy studies that have induced tumor regression ...
... an "abnormal" disease-causing gene. A carrier molecule called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, one of the most common vectors is a non- ...
... known as miRNAs are powerful natural repressors of gene expression. In the study, the miRNA miR-181a ... mouse bone marrow cells to express therapeutic genes only when miR-181a expression is downregulated ...
... University of New York at Stony Brook (SUNY) have developed a groundbreaking technique to sneak therapeutic genes past the body's defences, possibly clearing one of the largest hurdles to realising ...
... picogram per cell, the quantity of the magnetic material – and thus also the quantity of the therapeutically effective genes or cells. In a joint study with the University of Bonn it became clear: By ...
... of their treatment. The underlying cause of leukemia is thought to be that the viral vectors used to carry the therapeutic gene into cells (gamma-RVs) integrate into the genome of the cells disrupting ...
... Beyond muscular dystrophy, the discovery shows muscle tissue can be an effective avenue to deliver therapeutic genes for a variety of muscle disorders, including some that are resistant to treatment, ...
... or vectors. Most vectors have been derived from virusses that can be tailor-made to deliver therapeutic genes into the patients' cells. However, some of these viral vectors can induce side-effects, ...
... and neurodegenerative diseases (for example, Parkinson's or Alzheimer's). Now, a researcher in Spain has come up with a new approach that uses solid lipid nanoparticles to deliver therapeutic genes.
... test the efficacy of gene delivery, the hyaluron-coated nanoparticles were engineered to contain a therapeutic gene (Factor VIII) together with a genetic element known as Sleeping Beauty, which helps ...
