Science news articles about 'sonic hedgehog'

... School of Medicine researchers have discovered how the expression of the Sonic hedgehog gene is regulated during brain ... appear online this month in Nature Genetics. Sonic hedgehog (Shh) plays a key role ...

Researchers have discovered how the expression of the Sonic hedgehog gene is regulated during brain development and how mutations that alter this process cause brain malformations.

... of Medicine, St. Louis, have indicated a crucial role for signaling pathways that involve the protein sonic hedgehog in maintaining the blood vessels that supply the mouse heart and keep it beating.

... how the loss of the GPC3 gene induces overgrowth through certain growth factors such as Sonic Hedgehog which stimulate cancer growth. Published today in Developmental Cell, the study examines the ...

... Thus, the researchers theorized that Six3 might also trigger HPE by compromising the function of the Sonic Hedgehog pathway. For their first experiments, they turned to zebrafish, a widely used animal ...

... the brains of mice. This "conditional knock-out" method provoked changes in the so-called sonic hedgehog signalling pathway. Various processes in the development of nerve cells are controlled by this ...

... genesis of brain tumors is hypothetical and in the early stages of scientific discovery, the Sonic Hedgehog signaling mechanism appears to be one of the molecular mechanisms regulating both normal ...

... . 17, 10 to 11 a.m., poster presentation: "Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling." Hair-like projections called cilia exist on ...

... to turn into oligodendrocytes; it's often done by exposing these cells to a protein called Sonic Hedgehog, which produces oligodendrocytes in the spinal cord of developing embryos. Now Su-Chun Zhang ...

... molecules to lead them to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). Five years ago, as a postdoctoral fellow in the laboratory of Dr. Marc Tessier-Lavigne at ...

... much-studied signaling molecule called Sonic Hedgehog cruises between cells to direct their behavior, ... houses both the gas and brake pedals for Hedgehog signaling. " Targeting primary cilia with drugs ...