... 's and Parkinson's disease. The findings, published this past month in Nature Neuroscience, link the oxidation of potassium channels, which control a variety of cell functions ...
... scientists have made a significant advance in understanding how potassium channels, which permit the flow of electric currents ... of the gates and the gating process has remained unclear." Potassium channels are specialised pores in cell membranes ...
... to examine how the two variations affected the function of the potassium channel. They found that both variations suppressed a type ... Screening Facility, to find compounds that target the potassium channel and may be useful therapeutics for epilepsy. Kearney said that understanding ...
... models selectively eliminated their respective potassium ion channels, leading to a significant prolongation of the QT ... screen for and detect those drugs that interact with the HERG potassium channel, causing QT prolongation and potentially ...
... to simulate in unprecedented detail the voltage-gated potassium channel, a membrane protein that responds to spikes of electricity by changing shape to allow potassium ions to enter a cell. This work has the potential ...
... study, the researchers examined two channels that allow potassium ions to cross the cell membrane ... open and close much faster than other potassium channels. These channels are common in a portion of the brain called ...
... that were unable to reproduce sexually, were those with non-functioning potassium channels." The experiments had effectively disrupted the insect ... testing is also required to see whether the manipulation of the potassium channels may also affect the other stages of the parasites lifecycle ...
... cells. "There has been a large controversy in the field with regards to how these channels respond to voltage," said University of Illinois physics ... segment in a specific ion channel called the Shaker potassium channel. This protein was first discovered ...
... is caused by mutations in genes that encode important potassium channels in the pancreatic beta cells." The study ... , which controls insulin secretion by opening up crucial potassium channels in beta cells. However, this drug ...
... of the fetal brain by blocking acid sensitive potassium channels and preventing the acidic environment that alcohol ... by blocking acid sensitive potassium channels, known as TASK channels, that lead into the Purkinje cells ...
... of TPNLQ demonstrates that a highly specific inhibitor of potassium channels can be engineered. TPNLQ can now be used as a tool ... by plugging up renal Kir type 1 potassium channels is a potential new way to treat ...
... is known to control the opening and closing of certain potassium channels. Using a computational-experimental approach, researchers ... the physiological importance of sodium-mediated activation of potassium channels," Logothetis said. Cells in the kidney and specific ...
... treat the condition with a sulfonylurea and metformin, a drug that increases insulin sensitivity. Sulfonylureas bind to potassium channels on the surfaces of beta cells ...
... pancreatic beta cells to release insulin, which occurs when the drug inhibits ATP-sensitive potassium channels, causing calcium to enter the beta ...
... and neurological changes." "In contrast to sodium channels or potassium channels, there are very few diseases that cause ... previous researchers had observed defects in calcium channels in other cells, those cells did not have the coordinated electrical ...
