Science news articles about 'mutant p53'

... become stable in some cells, where it facilitates cancer formation and metastasis. The scientists found that mutant p53 is inherently unstable in normal tissues, but can become stable in some cells. ...

... time that phenethyl isothiocyante (PEITC), a naturally-occurring compound, can selectively deplete mutant p53. The authors also made an intriguing observation that the depletion of mutant p53 in ...

... p53 H/H with normal Mdm2, to 9 percent in mice lacking one copy of Mdm2 ... possibility of suppressing cancer metastasis by eliminating mutant p53 stability, which the researchers note is more feasible ...

... cell to kill itself. The trial showed that p53 expression in the patient's tumor before treatment ... whose tumor expressed high levels of mutant p53 before treatment. Patients with this unfavorable ...

... fails to carry out this vital function. That is why mutant p53 is a cancer-causing gene and is found in most human ... damaged cell avoids suicide due to p53, Chk1 or Chk2, there is another way it can kill ...

... first author and a U-M Ph.D. student in cell and developmental biology. The team found that mutant p53 was detectable in a minority of highly proliferative neural stem cells of p53-deficient mice two ...