Science news articles about 'mutant huntingtin'

... set out to investigate whether acetylation has a role in the disease. After first confirming that mutant huntingtin is acetylated by a specific group of enzymes, the researchers showed that mutant ...

... for dissecting the harmful effects of these protein aggregates in other diseases." The clumps of mutant huntingtin are also seen in the neuronal nucleus and cytoplasm in a recently established ...

... of the devastating neurological disorder. Scientists describe how an alteration to the mutated form of the huntingtin protein appears to accelerate its breakdown and removal through normal cellular ...

... disease. Before now, it was presumed that brain deposits of the mutant protein that causes the disease, called ... make IL-6 also make huntingtin, it's possible that mutant huntingtin might wrongly set ...

... single siRNA could shut off expression in the mutant Huntingtin gene – while leaving cells ... RNA, as it should. But sometimes it destroyed the normal Huntingtin RNA as well. To prevent this error, Zamore ...

... cells and brain cells taken from mice the researchers added different combinations of normal and mutant huntingtin and Rhes, and examined the cells over the next week to see if any cells died. ...

... expected to be extremely specific. "Our studies show that the use of intrabodies can block the parts of mutant huntingtin that cause its toxicity without affecting the wildtype, or normal, huntingtin— ...

... In the new study, researchers initially tested nerve cell cultures transfected with mutant Huntingtin protein and found that reducing excessive NMDA-type glutamate receptor activity with Memantine ...