... filling in the gaps left by the previous version of the mouse genome, a vast treasury of new genes ... Dr. Leo Goodstadt from the MRC Functional Genomics Unit.
"These new findings are extremely important ...
... . The study found just over 10,000 mutations in total, which together implicate almost 350 regions in the mouse genome in cancer formation. Fifty of these regions correspond to genes ...
... the results of extensive mouse studies into a comprehensive library to form a functional map of the mouse genome. Such a map will help researchers navigate and explore the even more extensive human ...
... mutant copies, the hair cells were already damaged at birth.
"When we mapped the mutation to the mouse genome, we quickly found a probable cause for hearing loss," explains senior author Professor ...
... ES cells maintain an open and active genome. This might very well be the secret of their success, ... occurs, the researchers created the first full-mouse genomic platform of DNA microarrays. Microarrays ...
... together implicate almost 350 regions in the mouse genome in cancer formation. 50 of these regions ... -first author on the paper from the NKI.
The infected mouse lines carried mutations in genes called ...
... cancer-specific set that target genes in the mouse genome.
By screening subsets or "pools" of them, ... synergy
After "knocking down" the Top2A gene in mouse lymphoma cells grown in culture, the team ...
... chips that catalog nearly every gene in the mouse genome, the researchers probed to see which genes ... linked to prostate cancer."
By comparing the list of mouse genes to genes whose human counterparts ...
... has produced laboratory results that are seemingly in disagreement: some ultraconserved elements can be deleted from the mouse genome and produce no observable effect on mice. Bejerano cautions that ...
... .
He then inserted a DNA tag into the mouse genome that allowed him to induce a break at ... We now know AID is causing damage in other parts of the genome, not just in antibody genes."
Because AID ...
... Broad Institute of Harvard and MIT. "The human and mouse genomes are already known to produce many large ... of four different types of mouse cells (including embryonic stem cells and cells from various ...
... circuits needed for vision, Shatz said, "but which ones?" There are about 60 in the mouse genome - and even more in the human genome.
The researchers found that two of those molecules in particular - ...
... predispose to cholesterol gallstone formation.
"The L-Fabp gene is located in a part of the mouse genome that appears likely to be involved in genetic susceptibility to gallstones," Davidson says. " ...
... genetic elements, transposons. PiRNAs have been shown to selectively silence transposons in the fly and mouse genomes. Due to their analysis the researchers assume that piRNAs have a similar function ...
... "knock down" the activity of specific genes and can be applied to practically every gene in the mouse genome.
"Our use of RNAi was essential," said Hacohen. "We couldn't have done this work without ...
