... discuss the history and future of mice as a model organism. They predict that the next frontiers in mouse genetics – such as creating mice expressing human genes to create "humanized" mice – will ...
Patients checking in to the German Mouse Clinic will undergo the most sophisticated medical testing in the world. But, finds Alison Abbott, the waiting list is becoming a problem.
... they utilise it to function."
"We showed that if you take a mouse genetically deficient in IL-21 and immunise ... sufficient, or normal, T cells into the same mouse, where of course the B cells remain ...
... animals.
Sacco used a trick to overcome these hurdles. She isolated satellite cells from a mouse genetically engineered to express a glowing protein, luciferase, first identified in fireflies. She ...
... maintain a youthful pattern gene expression into old age."
That's precisely what happened. Using a mouse genetically altered to model lymphoma, Oberdoerffer administered extra copies of the sirtuin ...
... G-loop salt bridge, combining molecular dynamics with structural modeling, biochemistry, and mouse genetics to decipher the importance of this structure.
In the molecular dynamics analysis of the ...
... renowned journal "Molecular Cell", that by employing methods from cell biology, biochemistry and mouse genetics, they have been able to identify a further protein, in addition to the known p62/SQSTM1 ...
... investigated how the host reacts to an infection," says Klaus Schughart, head of the Experimental Mouse Genetics research group. In infection experiments the researchers have now discovered that an ...
... if taken in high doses. But likely due to genetics, even the recommended dose can induce serious liver ... of North Carolina State University utilized mouse genetics to aid the search for candidate genes ...
... is a major regulator of cell fate decisions in developing cells from fruit flies to humans. Using mouse genetic models, the BU researchers inactivated Notch signaling in the lung and discovered that ...
... which showed that Mre11 both signals and repairs DNA damage.
Research details
The research team used complex mouse genetics to create mice with Mre11 mutations only in B ...
... "Now human ESC and iPS cell genetics can catch up to mouse genetics, which has had a 20-year headstart."
... routinely creating specific cell types for modeling genetic diseases (e.g., the brain cells ...
... 15 online edition of the American Journal of Human Genetics.
Elaine C. Davis, Ph.D., ... Montreal, Canada, compared various tissues from a mouse genetically engineered to be missing a form of the LTBP4 ...
... whose expertise on fever was crucial to our understanding". The work also demonstrates the importance of mouse genetics: the findings could not have arisen from work on isolated cell lines. Penninger ...
