... mitotic spindle, an apparatus that segregates chromosomes during cell division, may be more complex than the standard textbook ... (SEAS). The findings, which result from quantitative measurements of the mitotic spindle, will appear April 27 in the journal ...
... themselves, then line up in the middle of a structure, the mitotic spindle, which forms to aid cell division ... is important, because some cancer drugs interact with the mitotic spindle as a way to curb cell division ...
... tumours respond to the anti-mitotic drugs – which target the mitotic spindle (the structure that separates the chromosomes during cell division) – and revealed that the variation in cell behaviour ...
... in cell growth; inhibiting it leads to abnormal mitotic spindles – the structures that separate the chromosomes into daughter ... by inhibiting a key regulator of mitosis. They act on the mitotic spindle in a completely different manner compared ...
... are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell ...
... daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing ... tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular structural supports ...
... an identical set. The centrosomes' role is to construct the mitotic spindle, the axis along which the chromosome pairs ... cells with extra centrosomes form a single mitotic spindle, they pass through a brief 'multipolar ...
... , not for transportation. Dynamin 2 also clings to microtubules of the mitotic spindle, and the team next wants to determine whether the protein regulates microtuble dynamics during ...
... attach and move along proteins tracks (the mitotic spindle), from the centre of the cell to the poles. The centromere ... of proteins (called the kinetochore), which tether the chromosome to the spindle, and power its movement along the protein track ...
... of Cell Biology (www.jcb.org). The mitotic E2 enzyme UbcH10 partners with the anaphase ... of centrosomes that might complicate formation of a normal mitotic spindle. UbcH10 overexpression also reduced levels ...
... in tumor cells was caused by incorrect attachments between mitotic spindle microtubules and kinetochores, and that inducing misattachments in normal cells was sufficient to generate high rates ...
... involves the assembly and orientation of a structure called the "mitotic spindle." During mitosis, the proteins dynein ... . The researchers discovered that htt was specifically localized to the mitotic spindle during mitosis in mouse neurons ...
... has cracked. Researchers at the University of Oregon report that the mitotic spindle does not act alone -- that cortical ... is solely dependent on the position and symmetry/asymmetry of the mitotic spindle." First researchers used mutants that lack ...
An artificial mitotic spindle could help shed light on cell death and Down’s Syndrome
... ." The new findings grew out of studies of the so-called mitotic spindle in the one-celled amoeba Dictyostelium ... normally again. Specifically, they used a chemical that makes the spindles fall apart, and then they searched for genes ...
