... protein structure by solid-state NMR spectroscopy. The technique can be applied to a large range of membrane proteins and fibrils, which, because they are not water-soluble, are often not amenable to ...
Scientists can now describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out ...
... of sources and with a range of small molecules. Since about 60% of all drug targets are membrane proteins this is a significant discovery.
Ever since Professor Robinson first flew soluble protein ...
Australian scientists have mapped the anatomy of a membrane protein, adding to the worldwide pool of mapped proteins that can be used to design new drugs.
... Diamond Light Source national synchrotron facility in Oxfordshire. They used the MPL, which is a dedicated facility for membrane protein structural studies, to build an accurate picture of the Mhp1 ...
... P120 acts in cells by regulating the function of proteins called cadherins. Cadherins are membrane proteins that help cells stick to each other to form a tissue. On the outside of a cell's membrane, ...
... Universitaire sur le Médicament, two multidisciplinary research teams dedicated to the study of membrane protein functions and the identification of new therapeutic targets for drug discovery.
£5 million EPSRC initiative delivers a microfluidic tool to mine membrane proteins from cells
Researchers have developed a new general method to study membrane proteins. This method can be used to screen several thousand proteins, and it will reduce the way from development to useful drugs ...
... M findings challenge that notion. Instead, the researchers found that curcumin regulates the action of membrane proteins indirectly, by changing the physical properties of the membrane.
Ramamoorthy' ...
... structure of DAGK suggests that similar methods can now be used to study the structures of other membrane proteins.
"We're taking the methods that we used for diacylglycerol kinase and applying them ...
... the NMR structure of the bacterial protein diacylglycerol kinase, reported in the journal Science, suggests that similar methods can now be used to study the structures of other membrane proteins.
... Corp.)
GpA is a 131-amino acid protein that spans the human red-blood cell ... study, the team discovered something generally important about membrane proteins in general, too. They found that unlike ...
... . That boost in brightness — and therefore resolution — would be particularly important in the study of membrane proteins, which represent the vast majority of proteins of interest to those developing ...
... and which also shields the pathogen from oxidative stress. The researchers have found that the fungal protein TmpL is critical for the infection of host tissue and helps these pathogens regulate ...
